Abstract | BACKGROUND: METHODS: Chemical kindling was elicited by repeated intraperitoneal (ip) injections of a subconvulsant dose of PTZ (35 mg/kg) once every 48 hours for 12 times, and seizure activity of kindling was recorded for 30 minutes. Control rats were ip injected with saline instead of PTZ. Morris water maze was used to evaluate the spatial memory. Phosphorylated cyclic adenosine monophosphate response element binding protein (p-CREB) was tested by Western blotting in hippocampus. RESULTS: Intracerebroventricular (icv) injections with thioperamide (10 µg, 20 µg) 30 minutes before every PTZ injections, significantly prolonged the onset of PTZ-kindling and inhibited the seizure stages. PTZ-kindling seizures led to the impairment of spatial memory in rats, and thioperamide ameliorated the impairment of spatial learning and memory. Compared to non-kindling rats, there was a significant decrease in p-CREB level in hippocampus of the PTZ-kindling rats, which was reversed by thioperamide. CONCLUSIONS:
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Authors | Li-san Zhang, Jie-fang Chen, Guan-feng Chen, Xing-yue Hu, Mei-ping Ding |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 126
Issue 1
Pg. 95-100
(Jan 2013)
ISSN: 2542-5641 [Electronic] China |
PMID | 23286485
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Cyclic AMP Response Element-Binding Protein
- Histamine H3 Antagonists
- Neuroprotective Agents
- Piperidines
- thioperamide
- Pentylenetetrazole
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Topics |
- Animals
- Anticonvulsants
(pharmacology)
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Histamine H3 Antagonists
(pharmacology)
- Kindling, Neurologic
(drug effects)
- Male
- Memory Disorders
(prevention & control)
- Neuroprotective Agents
(pharmacology)
- Pentylenetetrazole
- Piperidines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Seizures
(prevention & control)
- Synaptic Transmission
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