[Pituitary adenomas with cells containing bêta MSH, alpha and bêta endorphins and without ACTH (author's transl)].

Abstract

By using immunohistoenzymatic techniques, cells of 4 pituitary adenomas are revealed with beta MSH, alpha and beta endorphins antisera but do not react with 1--24 and 17--39 ACTH antisera. These data suggest that adenomatous cells are able to synthesize and LPH-like molecule without ACTH. The levels of plasmatic LPH and beta MSH, studied by RIA, stay normal. These results are discussed.

• Authors: G Tramu, J C Beauvillain, M Mazzuca, F Girard, E Laine, J L Christiaens, J L Wemeau, P Fossati, M Linquette
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 40 Issue 6 Pg. 561-2 ( 1979) ISSN: 0003-4266 [Print] France
• Vernacular Title: Adénomes hypophysaires avec cellules à bêta MSH et à alpha et bêta endorphines sans ACTH.
• PMID: 232836 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endorphins
• Adrenocorticotropic Hormone
• Melanocyte-Stimulating Hormones
• beta-Lipotropin

Topics

• Adenoma (analysis)
• Adolescent
• Adrenocorticotropic Hormone (analysis)
• Adult
• Endorphins (analysis)
• Female
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Melanocyte-Stimulating Hormones (analysis, blood)
• Microscopy, Electron
• Middle Aged
• Pituitary Neoplasms (analysis)
• beta-Lipotropin (blood)