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[Prophylaxis against respiratory viral disease in pediatric and adult patients undergoing solid organ and hematopoietic stem cells transplantation].

Abstract
Respiratory viruses have been identified as a cause of morbidity and mortality in patients undergoing SOT and HSCT, specially in children. The most frequent are respiratory syncytial virus (RSV), influenza (FLU), parainfluenza (PI) and adenovirus (ADV). These infections are associated with progression to severe lower respiratory tract infections in up to 60% of the cases. It is advised to apply universal protection recommendations for respiratory viruses (A2) and some specific measures for FLU and AD. FLU: Annual anti-influenza vaccination (from 4-6 months post-transplantation in SOT, 6 months in HSCT (A2)); post- exposure prophylaxis in FLU (oseltamivir for 10 days (B2)). In lung transplantion, the prophylaxis should last as long as the risk period (B2). ADV: There is no vaccine nor valid chemoprophylaxis strategy to prevent ADV disease. In some specific HSCT recipients, weekly PCR monitoring is recommended until day+100 (A3).
AuthorsAna M Álvarez, Paula Catalán, Andrea Alba, Marcela Zubleta
JournalRevista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia (Rev Chilena Infectol) Vol. 29 Suppl 1 Pg. S33-6 (Sep 2012) ISSN: 0716-1018 [Print] Chile
Vernacular TitleProfilaxis de infection por virus respiratorios en niños y adultos sometidos a trasplante de órganos sólidos y precursores hematopoyéticos.
PMID23282554 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Antiviral Agents
  • Oseltamivir
Topics
  • Adenoviridae Infections (prevention & control)
  • Adult
  • Antiviral Agents (administration & dosage)
  • Child
  • Drug Administration Schedule
  • Humans
  • Incidence
  • Influenza, Human (epidemiology, prevention & control, virology)
  • Organ Transplantation
  • Oseltamivir (administration & dosage, therapeutic use)
  • Paramyxoviridae Infections (prevention & control)
  • Postoperative Complications (prevention & control)
  • Practice Guidelines as Topic
  • Respiratory Syncytial Virus Infections (epidemiology, prevention & control)
  • Risk Factors
  • Stem Cell Transplantation

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