Comparative study of systemic psoralen and ultraviolet A and narrowband ultraviolet B in treatment of chronic urticaria.
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| Abstract | BACKGROUND: Previous success rates of psoralen and ultraviolet A (PUVA) and narrowband UVB (NB-UVB) in the treatment of chronic urticaria are reported in few studies with no previous reports on the comparable efficacy of both modalities in the disease. AIM: We aimed to compare the efficacy of PUVA versus NB-UVB in the treatment of chronic urticaria. METHODS: Twenty-four patients with chronic urticaria were included and divided into two groups: 12 patients subjected to PUVA and 12 subjected to NB-UVB. They were compared according to the urticaria Total Severity Score (TSS) before and after treatment, cumulative dose, and side effects. RESULTS: There was a statistically significant decrease in urticaria TSS in both the NB-UVB- and PUVA-treated groups after than before treatment (P < 0.05), with no significant difference between both groups regarding the percentage of improved patients and the mean decrease of urticaria TSS (P > 0.05). Gastrointestinal upset was reported at a significantly higher percentage in the PUVA-treated group than in the NB-UVB-treated group. CONCLUSION: Both NB-UVB and PUVA show comparable efficacy in the treatment of chronic urticaria with minimal reversible side effects.
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| Authors | Naziha Hafez Khafagy, Samar Abdallah M Salem, Enas Guirguis Ghaly |
| Journal | Photodermatology, photoimmunology & photomedicine (Photodermatol Photoimmunol Photomed) Vol. 29 Issue 1 Pg. 12-7 (Feb 2013) ISSN: 1600-0781 [Electronic] England |
| PMID | 23281692 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial) |
| Copyright | © 2013 John Wiley & Sons A/S. |
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