Abstract |
Naturally occurring indole-3-carbinol and 3,3-diindolylmethane show bioactivity in a number of disparate disease areas, including cancer, prompting substantial synthetic analogue activity. We describe a new approach to highly functionalised derivatives that starts from allene gas and proceeds via the combination of a three-component Pd(0)-catalysed cascade with a one-pot, three-component carbophilic Pt(II) cascade linked to a stereoselective acid-catalysed Mannich-Michael reaction that generates complex cyclopropyl diindolylmethanes which show selective activity against prostate cancer cell lines.
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Authors | Nigel M Groome, Elghareeb E Elboray, Martyn W Inman, H Ali Dondas, Roger M Phillips, Colin Kilner, Ronald Grigg |
Journal | Chemistry (Weinheim an der Bergstrasse, Germany)
(Chemistry)
Vol. 19
Issue 6
Pg. 2180-4
(Feb 04 2013)
ISSN: 1521-3765 [Electronic] Germany |
PMID | 23280956
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antineoplastic Agents
- Cyclopropanes
- Indoles
- Palladium
- indole-3-carbinol
- 3,3'-diindolylmethane
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Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Catalysis
- Cell Line
(chemistry, drug effects)
- Cyclopropanes
(chemistry)
- Humans
- Indoles
(chemistry, pharmacology)
- Male
- Palladium
(chemistry)
- Prostatic Neoplasms
(chemistry, drug therapy)
- Stereoisomerism
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