Permanent conversion of NIH3T3 cells transformed by activated c-Ha-ras, c-Ki-ras, N-ras, or c-raf, and of human pancreatic adenocarcinoma containing activated c-Ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine.

• Authors: N Shindo-Okada, O Makabe, H Nagahara, S Nishimura
• Journal: Basic life sciences (Basic Life Sci) Vol. 52 Pg. 309-12 ( 1990) ISSN: 0090-5542 [Print] United States
• PMID: 2327940 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• beta-(5-hydroxy-2-pyridyl)alanine
• Alanine

Topics

• Adenocarcinoma (genetics, pathology)
• Alanine (analogs & derivatives, pharmacology)
• Animals
• Antibiotics, Antineoplastic (pharmacology)
• Cell Division (drug effects)
• Cell Line, Transformed (drug effects)
• Cell Transformation, Neoplastic (drug effects)
• Fibroblasts (drug effects)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Mice
• Mice, Nude
• Oncogenes
• Pancreatic Neoplasms (genetics, pathology)
• Tumor Cells, Cultured (drug effects)