Abstract | BACKGROUND: METHODS: The density of immature (CD1a(+)) and mature (CD83(+)) dendritic cells (DCs), cytotoxic T lymphocytes CD8(+) / perforin(+) (CTLs), and Foxp3(+) regulatory T (Tregs) cells in the lymph nodes of patients with OCSCC without cervical lymph node metastases (LN1) (negative) (n = 10) were identified through immunohistochemistry. From patients with cervical lymph node metastases, samples were obtained of lymph nodes both with (LM2) (positive) (n = 10) and without (LN2) (negative) (n = 10) metastases. RESULTS: The results demonstrated that the number of CD1a(+) and Foxp3(+) cells was significantly higher in the LM2 group than in either the LN1 or the LN2 group. In addition, the number of CD8(+) / perforin(+) and CD83(+) cells was significantly lower in the LM2 group than in the other groups. CONCLUSION: The results of this study demonstrate a higher density of immature DCs and Tregs cells and a lower density of mature DCs and activated CTLs in metastatic than in non-metastatic lymph nodes. These findings might indicate an immunosuppressive microenvironment, which could be involved in the spread of neoplastic cells to cervical lymph nodes.
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Authors | Andréia Souza Gonçalves, Nádia Lago Costa, Diego Antônio Costa Arantes, Rita de Cássia Gonçalves Alencar, Tarcília Aparecida Silva, Aline Carvalho Batista |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 42
Issue 7
Pg. 535-40
(Aug 2013)
ISSN: 1600-0714 [Electronic] Denmark |
PMID | 23278174
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Chemical References |
- Antigens, CD
- Antigens, CD1
- CD1a antigen
- CD8 Antigens
- CD83 antigen
- FOXP3 protein, human
- Forkhead Transcription Factors
- Immunoglobulins
- Membrane Glycoproteins
- PRF1 protein, human
- Pore Forming Cytotoxic Proteins
- Perforin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
(analysis)
- Antigens, CD1
(analysis)
- CD8 Antigens
(analysis)
- CD8-Positive T-Lymphocytes
(immunology)
- Carcinoma, Squamous Cell
(immunology, pathology)
- Cell Count
- Dendritic Cells
(immunology)
- Female
- Follow-Up Studies
- Forkhead Transcription Factors
(analysis)
- Humans
- Immune Tolerance
(immunology)
- Immunoglobulins
(analysis)
- Lymph Nodes
(immunology)
- Lymphatic Metastasis
(immunology, pathology)
- Lymphocyte Activation
(immunology)
- Male
- Membrane Glycoproteins
(analysis)
- Middle Aged
- Mouth Neoplasms
(immunology, pathology)
- Neck
- Perforin
- Pore Forming Cytotoxic Proteins
(analysis)
- Retrospective Studies
- T-Lymphocytes, Cytotoxic
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
- Tumor Microenvironment
(immunology)
- Young Adult
|