Abstract | OBJECTIVE: MATERIALS AND METHODS: Thirty VX2 tumor-bearing rabbits were randomized into three groups: the radiotherapy group, the irisquinone+radiotherapy group, and the control group, each comprising 10 rabbits. (18)F-FDG PET/CT images were obtained to monitor the tumor/muscle (T/M) ratio of F-FDG uptake and the retention index (RI) before treatment, when the radiation dose reached 6, 12, and 18 Gy, and 1 week after radiotherapy. Tumor volume changes were also assessed. The management of the control group followed the same procedure. RESULTS: At all treatment time points, the tumor volume was significantly smaller in the treatment groups than in the control group. The 1 and 2 h T/M ratios and RIs decreased gradually when the radiation dose reached 12 or 18 Gy in the treatment groups, whereas these values increased continuously in the control group. One week after treatment, the 1 and 2 h T/M ratios increased in the treatment groups, although these values remained lower than those in the control group. The RIs of the radiotherapy and irisquinone+radiotherapy groups were 0.329±0.133 and 0.137±0.036, respectively. Histological evaluation revealed that tumor F-FDG uptake was strongly related to tumor cell density. CONCLUSION:
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Authors | Huiqin Xu, Guoping Sun, Hui Wang, Qiao Yue, Hong Tang, Qiang Wu |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 34
Issue 3
Pg. 220-8
(Mar 2013)
ISSN: 1473-5628 [Electronic] England |
PMID | 23276827
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzoquinones
- Radiation-Sensitizing Agents
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
- irisquinone
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Topics |
- Animals
- Benzoquinones
(pharmacology)
- Cell Proliferation
- Dose-Response Relationship, Radiation
- Fluorodeoxyglucose F18
(pharmacology)
- Multimodal Imaging
(methods)
- Neoplasm Transplantation
- Positron-Emission Tomography
- Rabbits
- Radiation Tolerance
- Radiation-Sensitizing Agents
(pharmacology)
- Radiopharmaceuticals
(pharmacology)
- Time Factors
- Tomography, X-Ray Computed
- Treatment Outcome
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