Abstract |
The present study was designed to investigate the cardioprotective effect of neferine against isoproterenol-induced myocardial infarction. Neferine was given orally for 30 days, and isoproterenol was injected subcutaneously for 2 days. Histopathological examination of heart tissue of isoproterenol-treated rats showed myocardial necrosis. Biochemical analysis of isoproterenol-treated rats showed significant increase in the serum marker enzymes-- creatine kinase, lactate dehydrogenase, and aspartate transaminase and increased serum glycoprotein components with a concomitant decrease in the heart tissue homogenate when compared to control. Increased lipid peroxidation and decreased antioxidants reduced glutathione, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase and altered lipid profile in serum and tissue was also recorded in the isoproterenol-treated rats, whereas the rats which received neferine pre-treatment followed by isoproterenol injection showed minimal histological changes, absence of inflammation, and a significant decrease in the serum marker enzymes and serum glycoprotein components with a concomitant increase in the heart tissue homogenate when compared to isoproterenol group. Neferine pre-treatment restored the altered biochemical parameters and lipid profile to near normal. The results of the present study showed that neferine exerts strong antioxidant property against isoproterenol-induced oxidative stress and can be used as a potent cardioprotective agent against isoproterenol-induced myocardial infarction.
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Authors | Gurusamy Lalitha, Paramasivan Poornima, Arjunan Archanah, Viswanadha Vijaya Padma |
Journal | Cardiovascular toxicology
(Cardiovasc Toxicol)
Vol. 13
Issue 2
Pg. 168-79
(Jun 2013)
ISSN: 1559-0259 [Electronic] United States |
PMID | 23274852
(Publication Type: Journal Article)
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Chemical References |
- Benzylisoquinolines
- Biomarkers
- Cardiotonic Agents
- Drugs, Chinese Herbal
- Enzymes
- neferine
- Isoproterenol
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Topics |
- Animals
- Benzylisoquinolines
(pharmacology)
- Biomarkers
(metabolism)
- Cardiotonic Agents
(pharmacology)
- Drugs, Chinese Herbal
(pharmacology)
- Enzymes
(blood)
- Heart
(drug effects)
- Isoproterenol
(toxicity)
- Lipid Peroxidation
(drug effects)
- Male
- Myocardial Infarction
(blood, chemically induced, pathology, prevention & control)
- Myocardium
(enzymology, pathology)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Wistar
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