Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi.

Abstract

Even though the Chagas' disease, caused by the protozoan Trypanosoma cruzi, was described 100years ago by Carlos Chagas, it still represents a major public health concern and is found in 18 developing countries in South and Central America. In Brazil, Benznidazole (Rochagan) is the only drug with trypanocidal activity available in the market, despite its several side effects and limited efficacy in the chronic phase of the infection. In view of the need for new substances displaying biological activity against T. cruzi, there has been growing interest in research toward the attainment of compounds capable of acting on the parasite while being devoid of serious side effects. In this context, this study aims to evaluate the in vivo therapeutic activity of dibenzylbutyrolactone lignans (-)-cubebin and (-)-hinokinin during the acute phase of infection by T. cruzi. As a study criterion, animals with acute parasitemia were investigated by tissue morphometric analysis. There was significant parasitemia reduction in the groups of animals treated with (-)-cubebin or (-)-hinokin oral administration, compared to the negative control. Values close to those of the uninfected control were found in the groups treated with (-)-cubebin and (-)-hinokinin via kariometry, showing that there was positive cellular response compared to the infected control.

• Authors: Viviane Rodrigues Esperandim, Daniele da Silva Ferreira, Karen Cristina Souza Rezende, Wilson Roberto Cunha, Juliana Saraiva, Jairo Kenupp Bastos, Márcio Luis Andrade e Silva, Sérgio de Albuquerque
• Journal: Experimental parasitology (Exp Parasitol) Vol. 133 Issue 4 Pg. 442-6 (Apr 2013) ISSN: 1090-2449 [Electronic] United States
• PMID: 23274812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Benzodioxoles
• Dioxoles
• Lignans
• Nitroimidazoles
• Trypanocidal Agents
• hinokinin
• cubebin
• 4-Butyrolactone
• benzonidazole

Topics

• 4-Butyrolactone (analogs & derivatives, chemistry, pharmacology, therapeutic use)
• Animals
• Benzodioxoles
• Chagas Disease (drug therapy)
• Dioxoles (chemistry, pharmacology, therapeutic use)
• Lignans (chemistry, pharmacology, therapeutic use)
• Male
• Mice
• Mice, Inbred BALB C
• Nitroimidazoles (pharmacology, therapeutic use)
• Piper (chemistry)
• Trypanocidal Agents (chemistry, pharmacology, therapeutic use)
• Trypanosoma cruzi (drug effects)