Allo-HSCT for acute leukemia of ambiguous lineage in adults: the comparison between standard conditioning and intensified conditioning regimens.

Abstract

Knowledge concerning the clinical and biological characteristics of acute leukemia of ambiguous lineage (ALAL) is limited so that there has been a lack of uniformity in treatment. In this report, we retrospectively investigated the effect of intensified conditioning on adult ALAL undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). A total of 59 patients with ALAL (male in 37 cases and female in 22 cases) were consecutively enrolled in the data analyses. Twenty-four patients received the standard conditioning (total body irradiation (TBI) + cyclophosphamide (CY) or busulfan + CY protocol) and 35 received the intensified conditioning (TBI + CY + etoposide or fludarabine + cytarabine plus TBI + CY + etoposide protocol). Five-year transplant-related mortality was 17.6 ± 9.6 % and 25.5 ± 8.0 %, the 5-year overall survival (OS) post-transplantation was 23.8 ± 8.9 % and 64.0 ± 8.4 %, disease-free survival was 16.7 ± 7.6 % and 55.8 ± 9.4 %, the 5-year cumulative incidence of relapse was 80.8 ± 8.5 % and 28.8 ± 9.9 %, respectively, in the standard and the intensified group (P = 0.380, P = 0.029, P = 0.005, and P < 0.001). Both univariate and multivariate analysis indicated that the intensified conditioning regimen and acute graft-versus-host disease were favorable factors to reduce the relapse. The younger patients, patients with CR at the time of transplantation, and the intensified conditioning regimen were favorable factors to elevate the survival. In conclusion, intensified conditioning regimens followed by allo-HSCT might improve long-term survival and decrease relapse of leukemia in adult ALAL compared to the standard conditioning regimens.

• Authors: Qi-Fa Liu, Zhi-Ping Fan, Mei-Qing Wu, Jing Sun, Xiu-Li Wu, Dan Xu, Qian-Li Jiang, Yu Zhang, Fen Huang, Yong-Qiang Wei, Jie Zhao, Guo-Pan Yu, Fan-Yi Meng
• Journal: Annals of hematology (Ann Hematol) Vol. 92 Issue 5 Pg. 679-87 (May 2013) ISSN: 1432-0584 [Electronic] Germany
• PMID: 23274355 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunosuppressive Agents
• Cytarabine
• Etoposide
• Cyclophosphamide
• Busulfan

Topics

• Adolescent
• Adult
• Busulfan (administration & dosage, adverse effects)
• Child
• Cyclophosphamide (administration & dosage, adverse effects)
• Cytarabine (administration & dosage, adverse effects)
• Etoposide (administration & dosage, adverse effects)
• Female
• Graft vs Host Disease (epidemiology, etiology)
• Hematopoietic Stem Cell Transplantation (adverse effects, methods)
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects)
• Leukemia, Biphenotypic, Acute (diagnosis, epidemiology, therapy)
• Male
• Middle Aged
• Retrospective Studies
• Standard of Care
• Transplantation Conditioning (adverse effects, methods)
• Transplantation, Homologous
• Whole-Body Irradiation (methods)
• Young Adult