Granuloma formation has been shown to be induced and elicited by schistosome egg
antigens, and it finally develops into
fibrosis in intestine and the liver. Hepatic
fibrosis is the main cause of increased morbidity and mortality in humans infected with schistosomes.
Boswellic acid (BA)-containing extracts such as extracts of the oleogum resin from Boswellia serrata (BSE) have anti-inflammatory and immunomodulatory activity. However, little is known about the role of such extracts in schistosome egg-induced granulomatous
inflammation. In order to investigate the effect of a watersoluble
cyclodextrin complex preparation of BSE (BSE-CD) on Schistosoma japonicum (S. japonicum) egg-induced liver
granuloma, mice infected with S. japonicum cercariae were injected with BSE-CD during egg
granuloma formation. The data showed that BSE-CD significantly reduced the size of liver
granuloma and levels of serum
alanine aminotransferase (ALT) and
aspartate aminotransferase (AST); however, BSE-CD treatment had no effect on worm load and egg burden. The data also showed that BSE-CD significantly decreased the expression of
leukotriene B(4) (LTB(4)) and
prostaglandin E(2) (
PGE(2)), as well as the expression of matrix
metallopeptidase 9 (MMP-9) in liver both on the
mRNA and
protein level. Thus, BSE-CD can significantly attenuate S. japonicum egg-induced hepatic
granuloma, which may be partly dependent on the downregulation of some biochemical mediators.