The anticoagulant effect of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-6-hydroxyhexylamine, another amino-estrogen with prolonged anticoagulant effect.

Abstract	The anticoagulant and estrogenic effects of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-6-hydroxyhexylamine, are described. A single subcutaneous injection of hexolame in adult and infant male mice produced dose-dependent increases in blood clotting time which could be observed even after 2 days. In ovariectomized mice, hexolame produced vaginal cornification (estrogenic response). The data suggested that if used in the treatment of prostatic cancer, hexolame, like prolame, would not induce cardiovascular accidents. It could also be useful in the prevention of thrombosis.
Authors	C Rubio-Póo, C Lemini, J García-Mondragón, A de la Peña, V Jayme, N Mendoza-Patiño, E Zavala, G Silva, R T Blickenstaff, J M Fernández
Journal	Steroids (Steroids) Vol. 55 Issue 2 Pg. 83-6 (Feb 1990) ISSN: 0039-128X [Print] United States
PMID	2326832 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Amino Alcohols Anticoagulants Estrenes Estrogens hexolame
Topics	Amino Alcohols (pharmacology) Animals Animals, Newborn Anticoagulants Dose-Response Relationship, Drug Estrenes (pharmacology) Estrogens (pharmacology) Female Male Mice Thrombosis (prevention & control) Vaginal Diseases (drug therapy) Whole Blood Coagulation Time

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!