[A case report of liver metastasis of breast cancer successfully treated by hepatic arterial infusion of docetaxel and systemic administration of nab-paclitaxel].

Abstract

We report the case of an effectively treated 50-year-old woman with liver metastasis of left breast cancer. Her breast cancer (T2N0M0, Stage IIA) was resected in November 1998 (radical mastectomy+axillary lymph nodes dissection). After this operation, tamoxifen(TAM 20 mg daily) was administered. In February 2002, a solitary liver metastasis(S5, 4 cm in diameter) was found by computed tomography(CT) scan. Hepatic arterial infusion of docetaxel(DOC 20 mg weekly)was started. In March 2003, the solitary liver metastasis had become smaller and showed partial remission (PR), but DOC intravenous injection(iv) therapy(40 mg weekly) was started because lung metastases appeared. Therefore, epirubicin+ cyclophosphamide therapy, DOC ia therapy (120 mg triweekly), and anastrozole (1 mg daily) were continued. However, in March 2005, she refused chemotherapy. In January 2011, a CT scan showed progressive disease of multiple liver and lung metastases. Nab-paclitaxel(PTX) iv therapy(400 mg triweekly) and exemestane(25 mg daily) were administered. In March 2012, a CT scan showed PR of the metastatic breast cancer. She has continued to receive nab-PTX iv therapy as an outpatient.

• Authors: Eigo Satoh, Masakazu Ebuchi, Michio Maruyama, Naoya Akazawa, Keiichiro Suzuki, Daisuke Uehira, Shingo Ono, Kouji Yonekura, Ayano Murakata, Hideo Tanami, Shouji Maruyama, Norihide Sugano, Takaaki Sakoma
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 12 Pg. 2066-7 (Nov 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 23267978 (Publication Type: Case Reports, Journal Article)

Chemical References

• 130-nm albumin-bound paclitaxel
• Albumins
• Taxoids
• Docetaxel
• Paclitaxel

Topics

• Albumins (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Docetaxel
• Female
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged
• Paclitaxel (administration & dosage)
• Taxoids (administration & dosage)