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Concurrent pulmonary Aspergillus fumigatus and mucor infection in a cardiac transplant recipient: a case report.

Abstract
Invasive fungal infections are a significant complication of solid organ transplantation. Here we report the first case of concurrent invasive pulmonary fungal infection caused by Aspergillus fumigatus and Mucor species in a heart transplant recipient. Polymicrobial mold infection is rare but should be considered in solid organ transplant recipients who fail to respond to initial antifungal therapy targeting a single organism. It is also of interest that in addition to potent immunosuppression and prolonged voriconazole therapy, possible airway fungal colonization following hurricane Katrina cleaning efforts might have contributed to this dual invasive mold infection.
AuthorsB J Webb, J E Blair, S Kusne, R L Scott, D E Steidley, F A Arabia, H R Vikram
JournalTransplantation proceedings (Transplant Proc) Vol. 45 Issue 2 Pg. 792-7 (Mar 2013) ISSN: 1873-2623 [Electronic] United States
PMID23267784 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 Elsevier Inc. All rights reserved.
Chemical References
  • Antifungal Agents
  • Immunosuppressive Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole
Topics
  • Air Microbiology
  • Antifungal Agents (therapeutic use)
  • Cardiomyopathy, Dilated (surgery)
  • Cyclonic Storms
  • Environmental Exposure
  • Heart Transplantation (adverse effects, immunology)
  • Humans
  • Immunosuppressive Agents (adverse effects)
  • Invasive Pulmonary Aspergillosis (diagnosis, drug therapy, immunology, microbiology)
  • Male
  • Middle Aged
  • Mucormycosis (diagnosis, drug therapy, immunology, microbiology)
  • Pyrimidines (therapeutic use)
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Triazoles (therapeutic use)
  • Voriconazole

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