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Phytochemical analysis of the triterpenoids with cytotoxicity and QR inducing properties from the total tea seed saponin of Camellia sinensis.

Abstract
The tea seed triterpene saponin (TS) from Camellia sinensis was found to exhibit better antitumor activity in vivo in S180 implanted ICR mice and QR inducing activity for hepa lclc7 cells respectively compared with the total tea seed saponin (TTS), hydrolysate of the TTS and tea seed flavonoid glycosides (TF). By bioassay-guided isolation, the TS fraction was separated and seven major components were purified and identified as theasaponin E1 (1), theasaponin E2 (2), theasaponin C1 (3), assamsaponin C (4), theasaponin H1 (5), theasaponin A9 (6), and theasaponin A8 (7), among which compounds 4 and 5 were isolated from this genus for the first time. The antitumor bioassay of the isolated compounds showed that compounds 1, 2 and 3 exhibited potential activities against the human tumor cell lines K562 and HL60. Furthermore, compound 1 (the major constituent with a mass content of over 1%) showed significant QR inducing activity with an IR value of 4.2 at 4μg/ml. So it can be concluded that tea seed especially the compound 1 (theasaponin E1) could be used as an antitumor agent and a chemoprevention agent of cancer. The preliminary structure-activity relationship in the anti-tumor activity and QR inducing activity of tea saponins was discussed briefly.
AuthorsNing Li, Zhong-Jun Ma, Yang Chu, Ying Wang, Xian Li
JournalFitoterapia (Fitoterapia) Vol. 84 Pg. 321-5 (Jan 2013) ISSN: 1873-6971 [Electronic] Netherlands
PMID23266730 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Triterpenes
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
  • Camellia sinensis (chemistry)
  • Cell Line, Tumor
  • Humans
  • Male
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Saponins (chemistry, pharmacology)
  • Seeds (chemistry)
  • Triterpenes (chemistry, pharmacology)

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