Abstract | PURPOSE: METHODS: Clinical records of patients with pretreated advanced breast cancer and who were treated with the Metronomic-Cooper-type regimen consisting of weekly fixed doses of NPLD (30 mg IV) plus 5-Fluorouracil (5-FU) (500 mg IV) plus vincristine (0.25 mg IV) and daily oral cyclophosphamide (50 mg) plus prednisone (20 mg) were reviewed. RESULTS: In 84 pretreated patients, a tumor response was observed in 38 patients (45 %); stable disease was observed in 23 patients (27 %). Median progression-free survival (PFS) time to progression was 8.4 months and median overall survival (OS) was 21 months. The most common grade 2-3 hematologic adverse event was neutropenia, which was observed in 47 patients (56 %). Febrile neutropenia was observed in 10 patients (12 %). The most common non-hematologic adverse events were asthenia and mucositis which were observed in 60 patients (71 %) and 26 patients (31 %), respectively. Three patients (4 %) experienced an asymptomatic decline of the left ventricular ejection fraction. CONCLUSIONS: NPLD-based metronomic regimen was effective and safe in pretreated advanced breast cancer patients. It could be considered as an appealing option to treat patients previously exposed to anthracyclines.
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Authors | L Manso, N Valdiviezo, J Sepúlveda, E Ciruelos, C Mendiola, I Ghanem, E Vega, R Manneh, M Dorta, H Cortés-Funes |
Journal | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
(Clin Transl Oncol)
Vol. 15
Issue 6
Pg. 467-71
(Jun 2013)
ISSN: 1699-3055 [Electronic] Italy |
PMID | 23263907
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- liposomal doxorubicin
- Polyethylene Glycols
- Vincristine
- Doxorubicin
- Cyclophosphamide
- Fluorouracil
- Prednisone
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, mortality, pathology)
- Cyclophosphamide
(administration & dosage)
- Doxorubicin
(administration & dosage, analogs & derivatives)
- Female
- Fluorouracil
(administration & dosage)
- Follow-Up Studies
- Humans
- Middle Aged
- Neoplasm Grading
- Neoplasm Metastasis
- Polyethylene Glycols
(administration & dosage)
- Prednisone
(administration & dosage)
- Prognosis
- Retrospective Studies
- Safety
- Survival Rate
- Vincristine
(administration & dosage)
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