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The in vitro degradation process and biocompatibility of a ZK60 magnesium alloy with a forsterite-containing micro-arc oxidation coating.

Abstract
Magnesium has attracted much attention as a class of biodegradable metallic biomaterials. In this study, a silicate electrolyte-based micro-arc oxidation (MAO) treatment was adopted to prepare forsterite-containing MAO coatings on a ZK60 magnesium alloy in order to decrease the degradation rate and increase the biological property of the alloy. Four anodization voltages were chosen to prepare the MAO coatings. The cell experiment showed a cytotoxicity of grade 0 for the MAO-coated alloy to L929 cells and the hemolytic ratio was dramatically decreased for the MAO-coated alloy compared with the bare one. The corrosion resistance and the degradation behavior of the MAO-coated ZK60 alloy were studied using drop tests, electrochemical measurements and immersion tests. The results indicate that the MAO coating could effectively decrease the initial degradation rate of the alloy. The corrosion resistance of MAO coating was increased with the elevation of the preparation voltage. A degradation model for ZK60 alloy with a forsterite-containing MAO coating was proposed. Based on the model, the MAO-coated alloy experiences destruction and restoration simultaneously, and the coating fails in a peeling-off mode.
AuthorsXiao Lin, Lili Tan, Qiang Zhang, Ke Yang, Zhuangqi Hu, Jianhong Qiu, Yong Cai
JournalActa biomaterialia (Acta Biomater) Vol. 9 Issue 10 Pg. 8631-42 (Nov 2013) ISSN: 1878-7568 [Electronic] England
PMID23261923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Alloys
  • Coated Materials, Biocompatible
  • Silicon Compounds
  • Solutions
  • ZK60 magnesium alloy
  • forsterite
Topics
  • Absorbable Implants
  • Alloys (pharmacology)
  • Animals
  • Cell Survival (drug effects)
  • Coated Materials, Biocompatible (pharmacology)
  • Corrosion
  • Electrochemical Techniques
  • Fibroblasts (cytology, drug effects)
  • Hemolysis (drug effects)
  • Hydrogen-Ion Concentration
  • Materials Testing
  • Mice
  • Oxidation-Reduction
  • Silicon Compounds (pharmacology)
  • Solutions
  • Spectrometry, X-Ray Emission
  • X-Ray Diffraction

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