Abstract |
There is an urgent need to develop new drugs for the treatment of tuberculosis, particularly against latent/persistent forms of the causative agent, Mycobacterium tuberculosis. In this issue of Chemistry & Biology, Krieger and colleagues use a structure-guided approach to develop novel inhibitors of malate synthase, a target in the glyoxylate shunt that is critical for pathogen survival in chronic infection.
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Authors | Peter J Myler, Robin Stacy |
Journal | Chemistry & biology
(Chem Biol)
Vol. 19
Issue 12
Pg. 1499-500
(Dec 21 2012)
ISSN: 1879-1301 [Electronic] United States |
PMID | 23261593
(Publication Type: Comment, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2012 Elsevier Ltd. All rights reserved. |