Abstract |
To compare the efficacy of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2-year duration were randomized into two groups of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone. During the 6-week therapy period, a single weekly dose of 10 mg verapamil and 4 mg dexamethasone solution was administered to 30 patients in each group either by transdermal electromotive method or via the conventional injection method by a syringe connected to a 25 G needle. Evaluations of plaque length, width, and volume, penile curvature, erectile dysfunction and penile deviations were carried out before and after 1 and 3 months of the interventions. Erectile pain was reduced in the electromotive group from a mean of 5.1-1.0 in scale of 10 and from 5.4 to 3.6 in the injection group (p = 0.006). Regarding plaque length, plaque width, penile curvature plaque volume and erectile dysfunction, the electromotive administration group showed better results which, however, were not statistically significant. (p > 0.05). Transdermal electromotive drug administration yielded comparable results as against current conventional intra-lesional injection technique and fared better in controlling erectile pain.
|
Authors | A R Mehrsai, F Namdari, A Salavati, S Dehghani, F Allameh, G Pourmand |
Journal | Andrology
(Andrology)
Vol. 1
Issue 1
Pg. 129-32
(Jan 2013)
ISSN: 2047-2927 [Electronic] England |
PMID | 23258641
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Copyright | © 2012 American Society of Andrology and European Academy of Andrology. |
Chemical References |
- Calcium Channel Blockers
- Glucocorticoids
- Dexamethasone
- Verapamil
|
Topics |
- Administration, Cutaneous
- Analysis of Variance
- Calcium Channel Blockers
(administration & dosage)
- Dexamethasone
(administration & dosage)
- Drug Therapy, Combination
- Glucocorticoids
(administration & dosage)
- Humans
- Injections, Intralesional
- Iontophoresis
- Iran
- Male
- Penile Induration
(diagnosis, drug therapy)
- Prospective Studies
- Time Factors
- Treatment Outcome
- Verapamil
(administration & dosage)
|