The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis.

Abstract

We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports and our present cases show that anti-OJ autoantibody-positive interstitial lung disease (ILD) patients with PM/DM lack the manifestations of Raynaud's phenomenon and sclerodactyly and show good prognoses and responses to glucocorticoid therapy. These results indicate that the presence of anti-OJ autoantibodies may be useful for predicting the prognosis of ILD and its clinical course in PM/DM patients.

• Authors: Kei Kunimasa, Machiko Arita, Takashi Nakazawa, Maki Tanaka, Kazuya Tsubouchi, Satoshi Konishi, Yasushi Fukuda, Mika Saigusa, Hiroaki Nakagawa, Satoshi Ubukata, Yohei Korogi, Takao Fujii, Tsuneyo Mimori, Tadashi Ishida
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 24 Pg. 3405-10 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 23257529 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Isoleucine-tRNA Ligase

Topics

• Aged
• Autoantibodies (immunology)
• Dermatomyositis (complications, enzymology, immunology)
• Female
• Humans
• Isoleucine-tRNA Ligase (immunology)
• Lung Diseases, Interstitial (complications, enzymology, immunology)
• Male
• Polymyositis