Abstract | OBJECTIVE: METHODS AND RESULTS: The addition of taurine to the culture media ameliorated the reduced oxygen consumption, decreased the mitochondrial membrane potential, and increased the oxidative stress in MELAS patient-derived cells. Moreover, high dose oral administration of taurine (0.25 g/kg/day) completely prevented stroke-like episodes in two MELAS patients for more than nine years. CONCLUSION:
Taurine supplementation may be a novel potential treatment option for preventing the stroke-like episodes associated with MELAS.
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Authors | Mitsue Rikimaru, Yutaka Ohsawa, Alexander M Wolf, Kiyomi Nishimaki, Harumi Ichimiya, Naomi Kamimura, Shin-ichiro Nishimatsu, Shigeo Ohta, Yoshihide Sunada |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 51
Issue 24
Pg. 3351-7
( 2012)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 23257519
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Cells, Cultured
- Female
- Humans
- MELAS Syndrome
(complications, physiopathology)
- Mitochondria
(drug effects, physiology)
- Stroke
(etiology, prevention & control)
- Taurine
(pharmacology, therapeutic use)
- Young Adult
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