Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation.

Abstract

INTRODUCTION:

Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies.

AREAS COVERED:

In this article, the authors first review basic concepts of myocardial ischaemia/hibernation and relevant techniques to assess myocardial viability. Then, preclinical models of chronic myocardial ischaemia and hibernation, induced by devices such as ameroid constrictors, Delrin stenosis, hydraulic occluders, and coils/stents are described. Lastly, the authors discuss cell-based vasculogenic therapy, and summarise studies conducted in large animal models of chronic myocardial ischaemia and hibernation.

EXPERT OPINION:

Approximately one-third of patients with viable myocardium do not undergo revascularisation; however, this population is at high risk for cardiac events and would surely benefit from effective cell-based therapy. Because of the modest benefits in clinical studies, preclinical models accurately representing clinical myocardial ischemia/hibernation are necessary to better understand and appropriately direct regenerative therapy research.

• Authors: Céline Giordano, Drew Kuraitis, Rob S B Beanlands, Erik J Suuronen, Marc Ruel
• Journal: Expert opinion on biological therapy (Expert Opin Biol Ther) Vol. 13 Issue 3 Pg. 411-28 (Mar 2013) ISSN: 1744-7682 [Electronic] England
• PMID: 23256710 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Animals
• Chronic Disease
• Disease Models, Animal
• Humans
• Myocardial Ischemia (pathology)
• Myocardial Stunning (pathology)
• Neovascularization, Pathologic (pathology)