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Interferontherapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever.

Abstract
There is a clear need for novel, effective therapeutic approaches to hemorrhagic fever due to filoviruses. Ebola virus hemorrhagic fever is associated with robust interferon (IFN)-α production, with plasma concentrations of IFN-α that greatly (60- to 100-fold) exceed those seen in other viral infections, but little IFN-β production. While all of the type I IFNs signal through the same receptor complex, both quantitative and qualitative differences in biological activity are observed after stimulation of the receptor complex with different type I IFNs. Taken together, this suggested potential for IFN-β therapy in filovirus infection. Here we show that early postexposure treatment with IFN-β significantly increased survival time of rhesus macaques infected with a lethal dose of Ebola virus, although it failed to alter mortality. Early treatment with IFN-β also significantly increased survival time after Marburg virus infection. IFN-β may have promise as an adjunctive postexposure therapy in filovirus infection.
AuthorsLauren M Smith, Lisa E Hensley, Thomas W Geisbert, Joshua Johnson, Andrea Stossel, Anna Honko, Judy Y Yen, Joan Geisbert, Jason Paragas, Elizabeth Fritz, Gene Olinger, Howard A Young, Kathleen H Rubins, Christopher L Karp
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 208 Issue 2 Pg. 310-8 (Jul 15 2013) ISSN: 1537-6613 [Electronic] United States
PMID23255566 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Recombinant Proteins
  • Interferon-beta
Topics
  • Animals
  • Ebolavirus (drug effects)
  • Female
  • Hemorrhagic Fever, Ebola (drug therapy, virology)
  • Humans
  • Interferon-beta (pharmacology)
  • Macaca mulatta
  • Male
  • Marburg Virus Disease (drug therapy, virology)
  • Marburgvirus (drug effects)
  • Recombinant Proteins (pharmacology)

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