Abstract |
There is a clear need for novel, effective therapeutic approaches to hemorrhagic fever due to filoviruses. Ebola virus hemorrhagic fever is associated with robust interferon (IFN)-α production, with plasma concentrations of IFN-α that greatly (60- to 100-fold) exceed those seen in other viral infections, but little IFN-β production. While all of the type I IFNs signal through the same receptor complex, both quantitative and qualitative differences in biological activity are observed after stimulation of the receptor complex with different type I IFNs. Taken together, this suggested potential for IFN-β therapy in filovirus infection. Here we show that early postexposure treatment with IFN-β significantly increased survival time of rhesus macaques infected with a lethal dose of Ebola virus, although it failed to alter mortality. Early treatment with IFN-β also significantly increased survival time after Marburg virus infection. IFN-β may have promise as an adjunctive postexposure therapy in filovirus infection.
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Authors | Lauren M Smith, Lisa E Hensley, Thomas W Geisbert, Joshua Johnson, Andrea Stossel, Anna Honko, Judy Y Yen, Joan Geisbert, Jason Paragas, Elizabeth Fritz, Gene Olinger, Howard A Young, Kathleen H Rubins, Christopher L Karp |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 208
Issue 2
Pg. 310-8
(Jul 15 2013)
ISSN: 1537-6613 [Electronic] United States |
PMID | 23255566
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Recombinant Proteins
- Interferon-beta
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Topics |
- Animals
- Ebolavirus
(drug effects)
- Female
- Hemorrhagic Fever, Ebola
(drug therapy, virology)
- Humans
- Interferon-beta
(pharmacology)
- Macaca mulatta
- Male
- Marburg Virus Disease
(drug therapy, virology)
- Marburgvirus
(drug effects)
- Recombinant Proteins
(pharmacology)
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