[Side effects of sorafenib and countermeasures].

Abstract

Administration of more than 400 mg/day of sorafenib for 1 month prolonged progression-free survival (PFS) in Japanese patients with advanced renal cell carcinoma (RCC). This indicated that it is very important to prevent and manage side effects of sorafenib avoiding drug withdrawal or dose reduction. I mention the side effects of sorafenib and countermeasures in this review.

• Authors: Masashi Nakayama, Yasuyuki Arai, Kazuo Nishimura
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 58 Issue 11 Pg. 635-7 (Nov 2012) ISSN: 0018-1994 [Print] Japan
• PMID: 23254792 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Phenylurea Compounds
• Niacinamide
• Sorafenib

Topics

• Antineoplastic Agents (adverse effects)
• Carcinoma, Renal Cell (drug therapy)
• Humans
• Kidney Neoplasms (drug therapy)
• Molecular Targeted Therapy (adverse effects)
• Niacinamide (adverse effects, analogs & derivatives)
• Phenylurea Compounds (adverse effects)
• Sorafenib