Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne.

Abstract

BACKGROUND:

Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT.

AIMS:

To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne.

METHODS:

Thirty six patients with mild to moderate acne were enrolled. Eighteen patients recieved MAL-PDT and 18 received red light alone in two sessions, 2 weeks apart. Acne grade and lesion counts were assessed by blinded evaluators at baseline, 2, 4 and 10 weeks.

RESULTS:

At week 2, clinical improvement from acne grade II-IV to 0-I was observed in 82.3% of MAL-PDT group and 14.2% of red light alone group. Red light alone group had a gradual clinical improvement over time with a 77% response at week 10. In contrast, MAL-PDT group had a rapid clinical improvement with total response at week 10. Both treatments were significantly effective for improving acne lesions. However, MAL-PDT group had a greater response (P < 0.001). Histologically, decreased amounts of sebocytes and lipids along with atrophic sebaceous glands were observed after MAL-PDT.

CONCLUSION:

MAL-PDT has a quicker onset of action with a higher response than red light alone. MAL-PDT may induce a reduction in the size of the sebaceous glands and then long-term acne remission.

• Authors: Cristian Pinto, Fabiola Schafer, Juan Jose Orellana, Sergio Gonzalez, Ariel Hasson
• Journal: Indian journal of dermatology, venereology and leprology (Indian J Dermatol Venereol Leprol) 2013 Jan-Feb Vol. 79 Issue 1 Pg. 77-82 ISSN: 0973-3922 [Electronic] United States
• PMID: 23254733 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• methyl 5-aminolevulinate
• Aminolevulinic Acid

Topics

• Acne Vulgaris (drug therapy)
• Adolescent
• Adult
• Aminolevulinic Acid (analogs & derivatives, therapeutic use)
• Face
• Female
• Humans
• Light
• Male
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Severity of Illness Index
• Treatment Outcome
• Young Adult