HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo.

AbstractBACKGROUND:
Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was to examine whether brevican is a predictor of glioma and its roles in glioma cell motility.
METHODS:
In this study, immunohistochemistry staining for brevican expression was performed in malignant gliomas and benign controls. We also explored the effects of brevican on cell adhesion and migration in brevican-overexpressed cells. Knockdown of brevican expression was achieved by stable transfection of U251 cells transduced with a construct encoding a short hairpin DNA directed against the brevican gene, which correspondingly, down-regulated the proliferation, invasion and spread of brevican-expressing cells. Moreover, the role of brevican in the growth and progression of glioma was demonstrated by in vivo studies.
RESULTS:
Our results provide evidence for the molecular and cellular mechanisms that may underlie the motility-promoting role of brevican in the progression of glioma. The role of brevican as a target for immunotherapy might be taken into consideration in future studies.
CONCLUSIONS:
This study suggests that expression of brevican is associated with glioma cell adhesion, motility and tumor growth, and also is related to glioma cell differentiation, therefore it may be a marker for malignance degree of glioma.
AuthorsRenquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo, Huijie Wang, Jianbo Ding, Eric T Wong, Min Yu
JournalBMC cancer (BMC Cancer) Vol. 12 Pg. 607 (Dec 19 2012) ISSN: 1471-2407 [Electronic] England
PMID23253190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Brevican
  • Neoplasm Proteins
Topics
  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Blotting, Western
  • Brain Neoplasms (metabolism, pathology)
  • Brevican (antagonists & inhibitors, metabolism, physiology)
  • Cell Adhesion (physiology)
  • Cell Line, Tumor
  • Cell Movement (physiology)
  • Cell Proliferation
  • Female
  • Glioma (metabolism, pathology)
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Invasiveness (physiopathology)
  • Neoplasm Proteins (physiology)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: