Hepatic hypervitaminosis A: a familial observation.

Abstract

Four siblings with hepatic fibrosis are described. The liver damage in these patients was secondary to chronic ingestion of massive doses of vitamin A for congenital ichthyosis. Although the extrahepatic manifestations were helpful in the diagnosis of hypervitaminosis A, the distinctive features of hepatic histopathology were confirmatory. The plasma concentrations of vitamin A and retinol-binding protein were misleading. The recovery from the liver damage in these patients was slow despite a complete withdrawal of the vitamin A intake. These cases show the importance of hepatic vitamin A assessment in the diagnosis of hepatic fibrosis.

• Authors: J Sarles, C Scheiner, M Sarran, F Giraud
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 10 Issue 1 Pg. 71-6 (Jan 1990) ISSN: 0277-2116 [Print] United States
• PMID: 2324882 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vitamin A

Topics

• Adult
• Child
• Diagnosis, Differential
• Female
• Humans
• Hypervitaminosis A (chemically induced, diagnosis)
• Ichthyosis (drug therapy, genetics)
• Liver Cirrhosis (chemically induced, diagnosis)
• Male
• Vitamin A (adverse effects, therapeutic use)