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Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.

AbstractINTRODUCTION:
Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).
MATERIALS AND METHODOLOGY:
159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.
RESULTS:
Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).
CONCLUSIONS:
Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.
AuthorsHuang Yan, Lin Guoqiang, Chen Shengxi, Deng Zhenghao, Huang Lingjin
JournalThe open respiratory medicine journal (Open Respir Med J) Vol. 6 Pg. 135-8 ( 2012) ISSN: 1874-3064 [Electronic] United Arab Emirates
PMID23248718 (Publication Type: Journal Article)

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