Influence of antioxidant complex on the adhesion of leukocytes in chronic venous insufficiency of lower limbs in rats.

Abstract

OBJECTIVES:

In this study, we have evaluated the influence of antioxidant complex (AOC) (dihydroquercetin and lipoic acid) on pool of nonadhesive leukocytes and leukocytes with low and high adhesion in chronic venous insufficiency (CVI) of lower limbs in rats.

MATERIALS AND METHODS:

Model of CVI of lower limbs was created by blood flow restriction in caudal vena cava. AOC was administered at 100 mg/kg b.w./day for 14 days p.o. The venous pressure in vena cava and adhesion of leukocytes were estimated on the 14th day of the experiment.

RESULTS:

On the 14th day, the venous pressure in groups of animals (experimental and control) was in 2.7-2.9-fold higher. In the control group, the significant increase of leukocytes pool with high adhesion was detected. Intragastric administration of AOC reduced the number of leukocytes with high adhesion and increased the number of nonadhesive leukocytes and leukocytes with a low adhesion.

CONCLUSIONS:

Model of CVI of lower limb is accompanied by increased venous pressure and raised adhesion activity of leukocytes. Administration of AOC for 14 days reduces the adhesive activity of leukocytes.

• Authors: Mark Plotnikov, Ivan Ivanov, Anastasia Sidehmenova, Oleg Aliev, Nonna Tykavkina
• Journal: Indian journal of pharmacology (Indian J Pharmacol) 2012 Nov-Dec Vol. 44 Issue 6 Pg. 710-3 ISSN: 1998-3751 [Electronic] India
• PMID: 23248399 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Thioctic Acid
• Quercetin
• taxifolin

Topics

• Animals
• Antioxidants (administration & dosage)
• Cell Adhesion
• Leukocytes (drug effects, physiology)
• Lower Extremity (physiopathology)
• Male
• Quercetin (administration & dosage, analogs & derivatives)
• Rats
• Rats, Wistar
• Thioctic Acid (administration & dosage)
• Venous Insufficiency (drug therapy, physiopathology)
• Venous Pressure