Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: We consecutively studied 6,156 European diabetic patients attending clinics within 5 years of diagnosis (age range, 30-70 years) examined cross-sectionally clinically and for GAD antibodies (GADA) and antibodies to insulinoma-associated antigen-2 (IA-2A) and zinc-transporter 8 (ZnT8A). RESULTS: Of 6,156 patients, 541 (8.8%) had GADA and only 57 (0.9%) IA-2A or ZnT8A alone. More autoantibody-positive than autoantibody-negative patients were younger, leaner, on insulin (49.5 vs. 13.2%), and female (P < 0.0001 for each), though LADA patients (9.7% of total) did not show categorically distinct clinical features from autoantibody-negative type 2 diabetes. Similarly, more GADA patients with high (>200 World Health Organization IU) (n = 403) compared with low (n = 138) titer were female, lean, and insulin treated (54.6 vs. 39.7%) (P < 0.02 for each). Autoantibody-positive patients usually had GADA (541 of 598; 90.5%) and had LADA more often than type 1 autoimmune diabetes (odds ratio 3.3). CONCLUSIONS:
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Authors | Mohammed I Hawa, Hubert Kolb, Nanette Schloot, Huriya Beyan, Stavroula A Paschou, Raffaella Buzzetti, Didac Mauricio, Alberto De Leiva, Knud Yderstraede, Henning Beck-Neilsen, Jaakko Tuomilehto, Cinzia Sarti, Charles Thivolet, David Hadden, Steven Hunter, Guntram Schernthaner, Werner A Scherbaum, Rhys Williams, Sinead Brophy, Paolo Pozzilli, Richard David Leslie, Action LADA consortium |
Journal | Diabetes care
(Diabetes Care)
Vol. 36
Issue 4
Pg. 908-13
(Apr 2013)
ISSN: 1935-5548 [Electronic] United States |
PMID | 23248199
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Cation Transport Proteins
- ICA512 autoantibody
- SLC30A8 protein, human
- Zinc Transporter 8
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Topics |
- Adult
- Aged
- Autoantibodies
(immunology)
- Cation Transport Proteins
(immunology)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 1
(epidemiology, immunology)
- Europe
(epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Zinc Transporter 8
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