Abstract |
A fixed-dose co-formulated antiretroviral drug containing elvitegravir, a new integrase strand transfer inhibitor, boosted by a novel pharmacokinetic enhancer cobicistat, and further containing the nucleoside pair of tenofovir and emtricitabine was recently approved by the U.S. Food and Drug Administration as a single- tablet, once-a-day treatment of HIV-1 infection in antiretroviral therapy-naive adults. This drug was found to be noninferior to two currently preferred antiretroviral regimens in clinical practice in two large, 48-week, phase III studies. Renal adverse effects limit its use to those with creatinine clearance > 70 mL/min; its considerable drug interaction potential requires care and attention when used. Nevertheless, the availability of this fixed-dose combination product is an important progress in the management of HIV infection for a number of reasons: It provides a third option for a one-pill, once-a-day antiretroviral regimen; it is the first such regimen that is not based on a non- nucleoside reverse transcriptase inhibitor; and it provides an alternative to ritonavir for the pharmaco-enhancement of other antiretroviral drugs.
|
Authors | Z Temesgen |
Journal | Drugs of today (Barcelona, Spain : 1998)
(Drugs Today (Barc))
Vol. 48
Issue 12
Pg. 765-71
(Dec 2012)
ISSN: 1699-3993 [Print] Spain |
PMID | 23243633
(Publication Type: Journal Article, Review)
|
Copyright | Copyright 2012 Prous Science, S.A.U. or its licensors. All rights reserved. |
Chemical References |
- Anti-HIV Agents
- Carbamates
- Drug Combinations
- HIV Integrase Inhibitors
- Quinolones
- Thiazoles
- elvitegravir
- Cobicistat
|
Topics |
- Anti-HIV Agents
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Antiretroviral Therapy, Highly Active
(methods)
- Carbamates
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Cobicistat
- Drug Approval
- Drug Combinations
- Drug Interactions
- Drug Resistance, Viral
- HIV Infections
(drug therapy, virology)
- HIV Integrase Inhibitors
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Humans
- Patient Safety
- Quinolones
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Thiazoles
(administration & dosage, adverse effects, pharmacology, therapeutic use)
|