Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding.

Abstract

BACKGROUND:

Aspiration pneumonia is an emerging problem in patients receiving gastrostomy feeding. This study is designed to clarify the therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding.

METHODS:

The study subjects were 119 patients with dysphasia who required gastrostomy feeding. They were randomly assigned to the control (without medication), lansoprazole (15 mg, 1/day), and mosapride (5 mg, 3/day) groups. The number of days with fever (≥37.8 °C), vomiting, and antibiotics administration, as well as the occurrence of pneumonia were investigated during the 6-month observation period.

RESULTS:

The incidence of pneumonia during the observation period was significantly lower in the mosapride group as compared to the control (7/38 vs. 16/40, p = 0.038) and lansoprazole (vs. 20/41, p = 0.005) groups. The mosapride group also showed a significant decrease in days with fever and antibiotics administration as compared to the other groups. Multivariate analysis revealed that the presence of hiatal hernia was a significant risk factor and administration of mosapride was a significant preventive factor for pneumonia.

CONCLUSION:

Mosapride has a preventive effect on occurrence of pneumonia in patients receiving gastrostomy feeding.

• Authors: Kento Takatori, Rihito Yoshida, Aya Horai, Shinya Satake, Takayuki Ose, Naoto Kitajima, Shushi Yoneda, Kyoichi Adachi, Yuji Amano, Yoshikazu Kinoshita
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 48 Issue 10 Pg. 1105-10 (Oct 2013) ISSN: 1435-5922 [Electronic] Japan
• PMID: 23238778 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Ulcer Agents
• Benzamides
• Morpholines
• Serotonin Receptor Agonists
• Lansoprazole
• mosapride

Topics

• Aged
• Aged, 80 and over
• Anti-Ulcer Agents (therapeutic use)
• Benzamides (therapeutic use)
• Drug Therapy, Combination
• Enteral Nutrition
• Female
• Gastrostomy
• Humans
• Incidence
• Lansoprazole (therapeutic use)
• Male
• Middle Aged
• Morpholines (therapeutic use)
• Pneumonia, Aspiration (prevention & control)
• Prospective Studies
• Serotonin Receptor Agonists (therapeutic use)
• Treatment Outcome