Abstract | PURPOSE: Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) and a rat-derived pancreatic β-cell line (RIN-5F cells) and to investigate its effect in type 2 diabetic model ob/ob mice. METHODS: RESULTS: CONCLUSIONS:
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Authors | Myoung Jin Son, Miki Minakawa, Yutaka Miura, Kazumi Yagasaki |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 52
Issue 6
Pg. 1607-19
(Sep 2013)
ISSN: 1436-6215 [Electronic] Germany |
PMID | 23238530
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Blood Glucose
- Chalcones
- Glucose Transporter Type 4
- Hypoglycemic Agents
- Insulin
- Leptin
- Reactive Oxygen Species
- aspalathin
- Cholesterol
- AMP-Activated Protein Kinases
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Topics |
- AMP-Activated Protein Kinases
(genetics, metabolism)
- Adiponectin
(blood)
- Animals
- Blood Glucose
(drug effects, metabolism)
- Body Weight
- Cell Line
- Chalcones
(pharmacology)
- Cholesterol
(blood)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Gluconeogenesis
(drug effects)
- Glucose Intolerance
(drug therapy)
- Glucose Transporter Type 4
(genetics, metabolism)
- Glycogenolysis
(drug effects)
- Hyperglycemia
(drug therapy)
- Hypoglycemic Agents
- Insulin
(blood)
- Insulin-Secreting Cells
(drug effects, metabolism)
- Leptin
(blood)
- Lipogenesis
(drug effects)
- Mice
- Mice, Obese
- Muscle Fibers, Skeletal
(drug effects, metabolism)
- Muscle, Skeletal
(cytology, drug effects)
- Phosphorylation
- Rats
- Reactive Oxygen Species
(metabolism)
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