Abstract | BACKGROUND: PATIENTS AND METHODS: A 23-year-old woman had a history of a chronic pruritic papular-vesicular eruption on the trunk, present since the onset of puberty and unsuccessfully treated with antihistamines and topical steroids. Skin lesions normally began a few days before menstruation and resolved a few days afterwards. Intradermal testing using progesterone was positive, thereby confirming the diagnosis. The patient's skin lesions improved under oral contraceptives designed to inhibit ovulation and there was no relapse during subsequent menstrual cycles. DISCUSSION:
AIPD is a rare autoimmune disorder. The diagnostic criteria of AIPD include recurrent cyclical worsening of skin lesions and symptomatic improvement after inhibition of progesterone secretion by suppression of ovulation. The pathogenesis is unclear. Positive response to various tests with progesterone suggests involvement of various mechanisms such as antibodies and/or cell-mediated immune reactions. CONCLUSION:
AIPD is a rare disease that can seriously affect patients' quality of life and which may even be life-threatening in certain cases.
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Authors | Z Lahmam Bennani, N El Fekih, D Baccouche, A Khaled, F Zaglaoui, B Fazaa |
Journal | Annales de dermatologie et de venereologie
(Ann Dermatol Venereol)
Vol. 139
Issue 12
Pg. 832-5
(Dec 2012)
ISSN: 0151-9638 [Print] France |
Vernacular Title | Dermatose auto-immune à la progestérone. |
PMID | 23237283
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2012 Elsevier Masson SAS. All rights reserved. |
Chemical References |
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Topics |
- Autoimmune Diseases
(diagnosis, drug therapy)
- Dermatitis
- Female
- Humans
- Progesterone
(adverse effects)
- Young Adult
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