The frequency of gall bladder lesions in
cholecystectomies is not clear. The purpose of the present study is to report the morphologies and frequency of
gall bladder diseases and lesions of 540
cholecystectomies in the last 10 years in our pathology laboratory. The age of patients ranged from 18 years to 93 years with a mean of 64.75 ±14.43 years. Male to female ratio was 213:327. Of these, 518 cases (96%) had
gall stones. Eight (1.5%) were
acute cholecystitis, 508 (94.1%) were chronic
cholecystitis, 12 (2.2%) were
adenocarcinomas, 1 (0.2%) was
cystadenocarcinoma, and 11 (2.0%) were normal gall bladders. The frequency of histological lesions were as follows: acute gangrenous
inflammation (8 cases, 1.5%), Rokitansky-Aschoff sinuses (RAS) (351 cases, 65%), microliths or inspissated bile in RAS (108 cases, 20%), adenomyomatous changes (16 cases, 3.0 %), focal
abscess formations (12 cases, 2.2%), focal xanthogranulomatous changes (15 cases, 2.8%), mucosal
ulcers (61 cases, 11.3%), cholesterosis (62 cases, 11%),
cholesterol polyp (32 cases, 6%), pyloric gland
metaplasia (292 cases, 54%),
adenoma (7 cases, 1.3%),
xanthogranulomatous cholecystitis (5 cases, 1%), invasive
adenocarcinoma (12 cases, 2.2%), and
cystadenocarcinoma (1 cases, 0.2%). In adenomyomatous changes, the epithelial proliferation was florid in a few cases, and no perineural invasions were seen. In pyloric gland
metaplasia, no perineural invasions were recognized. All the 7 cases of
adenoma were of intestinal type. In the 12
adenocarcinoma cases, one case arose in RAS without mucosal involvement, and 9 were
tubular adenocarcinomas and 3 were
papillary adenocarcinomas and 1 was
mucinous adenocarcinoma. In the present series, there were no cases of heterotipc tissue, intestinal
metaplasia,
intraepithelial neoplasm, and other
malignancies. These data may provide basic knowledge of the gall bladder pathologies.