Application of interventional bronchoscopic therapy in eight pediatric patients with malignant airway tumors.

Abstract

AIMS AND BACKGROUND:

Malignant airway tumors in children have rarely been reported. We evaluated the safety and therapeutic effects of interventional bronchoscopic therapy in 8 children with malignant airway tumors.

METHODS AND STUDY DESIGN:

We retrospectively analyzed 8 children with malignant airway tumors diagnosed by pathology, and evaluated their clinical features, chest computer tomography findings and bronchoscopic manifestations.

RESULTS:

Two of the 8 pediatric patients had high-grade malignancies (lymphoma and sarcoma) and the others all had low-grade malignancies, including 2 cases with mucoepidermoid carcinoma and 4 cases with inflammatory myofibroblastic tumor. Their ages ranged from 4 to 8 years (mean, 5.7 ± 0.9). There were no specific clinical manifestations in the children, and all of them presented with various respiratory symptoms, including cough and gasping associated with hemoptysis. Chest CT indicated round intra-airway neoplasms. Obstructive pulmonary atelectasis occurred in the main bronchus of 4 patients (3 cases of the left main bronchus and 1 case of the right intermedius bronchus). All children (1 case with local anesthesia and 7 cases with general anesthesia) underwent interventional bronchoscopic therapy, including argon plasma coagulation and CO 2 cryosurgery. The success rate for the rigid procedures was 100.0% (7/7), and the cure rate after 3 months was 85.7% (6/7). A part of the tumor remained in the lung of 1 patient with inflammatory myofibroblastic tumor after bronchoscopic treatment. One patient with local anesthesia died of suffocation caused by tumor consolidation during the bronchoscopic procedure. There were no recurrences in 6 patients during the follow-up period. One recurred patient was cured at 6 months.

CONCLUSIONS:

There are no specific manifestations in children with malignant airway tumors. Interventional bronchoscopic therapy seems to be safe and effective for those tumors under general anesthesia.

• Authors: Hongwu Wang, Nan Zhang, Meimei Tao, Dongmei Li, Yunzhi Zhou, Hang Zou, Sujuan Liang, Jing Li
• Journal: Tumori (Tumori) 2012 Sep-Oct Vol. 98 Issue 5 Pg. 581-7 ISSN: 2038-2529 [Electronic] United States
• PMID: 23235752 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carbon Dioxide

Topics

• Anesthesia, General
• Argon Plasma Coagulation
• Bronchial Neoplasms (complications, diagnosis, pathology, surgery)
• Bronchoscopy (methods)
• Carbon Dioxide (therapeutic use)
• Carcinoma, Mucoepidermoid (diagnosis, surgery)
• Child
• Child, Preschool
• Cough (etiology)
• Cryosurgery (methods)
• Delayed Diagnosis
• Diagnosis, Differential
• Diagnostic Errors
• Dyspnea (etiology)
• Female
• Hemoptysis (etiology, therapy)
• Humans
• Lymphoma (diagnosis, surgery)
• Male
• Neoplasms, Muscle Tissue (diagnosis, surgery)
• Retrospective Studies
• Sarcoma (diagnosis, surgery)
• Treatment Outcome