[Comparative study of himantane and amantadine effects in experimental intracerebral posttraumatic hematoma].

Abstract

Effects of the novel antiparkinsonian drug himantane and amantadin were studied in rats with intracerebral posttraumatic hematoma. Drugs were administered first at 3.5 hours after surgery and then for 4 consecutive days. Effects were registered on days 1, 3, 7 and 14 after surgery. It was shown that both drugs significantly decreased mortality and improved motor activity, exploratory behavior and memory. Amantadin was more effective in tests for motor activity and exploratory behavior. Himantane 5 mg/kg i.p demonstrated the more pronounced activity in restoring memory. The results obtained testify for neuroprotective properties of the novel antiparkinsonian drug himantane.

• Authors: S O Kotel'nikova, A V Nepoklonov, I I Kokshenev, E A Ivanova, V A Kraĭneva, E A Val'dman, T L Garibova, T A Voronina
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 112 Issue 9 Pg. 63-6 ( 2012) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 23235415 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiparkinson Agents
• N-(2-adamantyl)hexamethylenimine
• Amantadine
• Adamantane

Topics

• Adamantane (analogs & derivatives, therapeutic use)
• Amantadine (therapeutic use)
• Animals
• Antiparkinson Agents (therapeutic use)
• Cerebral Hemorrhage, Traumatic (drug therapy, psychology, rehabilitation)
• Disease Models, Animal
• Exploratory Behavior (drug effects)
• Male
• Memory (drug effects)
• Muscle Tonus (drug effects)
• Rats