Abstract | INTRODUCTION: Single-dose pharmacokinetics of orbifloxacin (2.5mg/kg body weight) were determined in clinically normal female Patanwadi sheep (n=6) following intravenous and intramuscular administration. METHODS:
Orbifloxacin concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration-time data were analyzed by non-compartmental kinetic method. RESULTS AND DISCUSSION: Following a single intravenous injection, an elimination half-life (t(1/2β)) of 8.31±0.102h. Steady-state volume of distribution (Vd(ss)) and total body clearance (Cl(B)) were 3.09±0.282L/kg and 0.158±0.006L/kg/h, respectively. Following intramuscular administration, an elimination rate constant (β), the area under the curve from zero to infinity (AUC(0-∞)) and the mean absorption time (MAT) were 0.015±0.001h(-1), 23.49±1.722μg·h/mL and 7.50±0.58h, respectively. The peak plasma concentration (C(max)) of 1.81±0.005µg/mL was achieved at 1.00±0.00h. The mean residence time (MRT) was 26.25±1.083h and the absolute bioavailability was 150.8±12.35%, respectively. Orbifloxacin could be useful for the treatment of bacterial infections in sheep that are sensitive to this drug.
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Authors | G B Dudhatra, Avinash Kumar, M M Awale, D R Kamani, B N Chauhan, H B Patel, S K Mody |
Journal | Journal of pharmacological and toxicological methods
(J Pharmacol Toxicol Methods)
2013 Jan-Feb
Vol. 67
Issue 1
Pg. 50-3
ISSN: 1873-488X [Electronic] United States |
PMID | 23231925
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Ciprofloxacin
- orbifloxacin
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Topics |
- Administration, Intravenous
- Animals
- Chromatography, High Pressure Liquid
(methods)
- Ciprofloxacin
(administration & dosage, analogs & derivatives, analysis, blood)
- Female
- Injections, Intramuscular
- Sheep
(blood)
- Species Specificity
- Spectrophotometry, Ultraviolet
(methods)
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