Contact allergy to Bronopol.

Abstract

A total of 8149 patients were patch tested with the preservative Bronopol in 7 European contact clinics. The majority of patients (6507) were investigated in London. Reactivity was low, with a total of 10 irritant (0.12%) and 38 allergic reactions (0.47%). In only 17 cases (0.21%) was the patch test reaction to Bronopol considered to be of current or past clinical relevance. Concomitant sensitization to formaldehyde was present in about 1/3 of patients. Based on these figures, the present sensitization rate to Bronopol in Europe seems to be quite low, which may be related to its less frequent use as a preservative in cosmetics and medicaments in comparison to parabens or isothiazolinones.

• Authors: P J Frosch, I R White, R J Rycroft, A Lahti, D Burrows, J G Camarasa, G Ducombs, J D Wilkinson
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 22 Issue 1 Pg. 24-6 (Jan 1990) ISSN: 0105-1873 [Print] England
• PMID: 2323186 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Cosmetics
• Propylene Glycols
• Formaldehyde
• bronopol

Topics

• Adolescent
• Adult
• Aged
• Anti-Infective Agents (immunology)
• Cosmetics (adverse effects)
• Dermatitis, Contact (etiology, immunology)
• Female
• Formaldehyde (immunology)
• Humans
• London
• Male
• Middle Aged
• Patch Tests (methods)
• Propylene Glycols (adverse effects, immunology)
• Sex Factors