Abstract | OBJECTIVES: MATERIALS AND METHODS: HSP70, TGF-β2, Caspase 7 and INF-γ as biochemical parameters related to inflammation were determined in plasma of 20 Saudi autistic male patients and compared to 19 age- and gender-matched control samples. RESULTS: The obtained data recorded that Saudi autistic patients have remarkably higher plasma HSP70, TGF-β2, Caspase 7 and INF-γ compared to age and gender-matched controls. INF-γ recorded the highest (67.8%) while TGF-β recorded the lowest increase (49.04%). Receiver Operating Characteristics (ROC) analysis together with predictiveness diagrams proved that the measured parameters recorded satisfactory levels of specificity and sensitivity and all could be used as predictive biomarkers. CONCLUSION: Alteration of the selected parameters confirm the role of neuroinflammation and apoptosis mechanisms in the etiology of autism together with the possibility of the use of HSP70, TGF-β2, Caspase 7 and INF-γ as predictive biomarkers that could be used to predict safety, efficacy of a specific suggested therapy or natural supplements, thereby providing guidance in selecting it for patients or tailoring its dose.
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Authors | Afaf El-Ansary, Laila Al-Ayadhi |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 9
Pg. 265
(Dec 11 2012)
ISSN: 1742-2094 [Electronic] England |
PMID | 23231720
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HSP70 Heat-Shock Proteins
- Transforming Growth Factor alpha
- Interferon-gamma
- Caspase 7
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Topics |
- Adolescent
- Case-Control Studies
- Caspase 7
(blood)
- Child
- Child Development Disorders, Pervasive
(blood)
- Child, Preschool
- Fasting
- Female
- HSP70 Heat-Shock Proteins
(blood)
- Humans
- Interferon-gamma
(blood)
- Male
- ROC Curve
- Transforming Growth Factor alpha
(blood)
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