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Early amniocentesis and amniotic fluid organic acid levels in the prenatal diagnosis of organic acidemias.

Abstract
Organic acids were studied in amniotic fluids taken by early amniocentesis between 6 to 12 weeks in control pregnancies. The prenatal diagnosis of methylmalonic acidemia and propionic acidemia could be made by the measurement of methylmalonic and methylcitric acid respectively in the amniotic fluid taken simultaneously with chorionic villi at the 11th week of gestation.
AuthorsM Coude, B Chadefaux, D Rabier, P Kamoun
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 187 Issue 3 Pg. 329-32 (Mar 15 1990) ISSN: 0009-8981 [Print] Netherlands
PMID2323072 (Publication Type: Journal Article)
Chemical References
  • Carboxylic Acids
Topics
  • Acidosis (diagnosis)
  • Amniocentesis
  • Amniotic Fluid (analysis)
  • Carboxylic Acids (analysis)
  • Female
  • Fetal Diseases (diagnosis)
  • Humans
  • Pregnancy
  • Reference Values

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