[Assessment of endogenous thrombin potential and influence on it of different regimens of heparin therapy in patients with abdominal sepsis].

Abstract

Abdominal sepsis (AS) is a systemic inflammatory reaction of organism in response to the development of infectious process in organs of the abdominal cavity. The course of AS is complicated by hypercoagulation syndrome which facilitates progression of endogenous intoxication. The investigation included 26 patients (14 men and 12 women, mean age 65.5 +/- 16.4 years) with AS. The test of thrombin generation (TTG) used in patients with AS allows assessment of changes in the hemostasis system and control of the heparin dose. It was established that TTG revealed elevated endogenous thrombin potential of blood practically in all patients with AS. In the patients given 25 000 IU of heparin the TTG indices showed a reliably decreased endogenous thrombin potential and peak thrombin concentration as compared with a group of patients given 10 000 IU of heparin.

• Authors: Kh A Gamzatov, D V Gurzhiĭ, S M Lazarev, Iu A Nemestnikov, A A Gurzhiĭ, L P Panaian, O G Golovina, E A Khait, O A Smirnova, O Iu Matvienko
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 171 Issue 5 Pg. 31-6 ( 2012) ISSN: 0042-4625 [Print] Russia (Federation)
• PMID: 23227740 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Heparin
• Thrombin

Topics

• Abdomen
• Aged
• Anticoagulants (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Heparin (administration & dosage)
• Humans
• Male
• Sepsis (blood, drug therapy)
• Thrombin (drug effects, metabolism)
• Treatment Outcome