A peptide nanofibrous indicator for eye-detectable cancer cell identification.

Abstract

A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection.

• Authors: Chang-Sheng Chen, Xiao-Ding Xu, Ya Wang, Juan Yang, Hui-Zhen Jia, Han Cheng, Chih-Chang Chu, Ren-Xi Zhuo, Xian-Zheng Zhang
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 9 Issue 6 Pg. 920-6 (Mar 25 2013) ISSN: 1613-6829 [Electronic] Germany
• PMID: 23225693 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Peptides

Topics

• Amino Acid Sequence
• Animals
• COS Cells
• Carcinoma, Hepatocellular (diagnosis)
• Chlorocebus aethiops
• Color
• Hep G2 Cells
• Humans
• Liver Neoplasms (diagnosis)
• Molecular Sequence Data
• Nanofibers
• Peptides (chemistry)
• Vision, Ocular