Transcriptional regulation of ncx1 gene in the brain.

Abstract

The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a -bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca(2+) and Na(+) homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.

• Authors: Valeria Valsecchi, Giuseppe Pignataro, Rossana Sirabella, Carmela Matrone, Francesca Boscia, Antonella Scorziello, Maria Josè Sisalli, Elga Esposito, Nicola Zambrano, Mauro Cataldi, Gianfranco Di Renzo, Lucio Annunziato
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 961 Pg. 137-45 ( 2013) ISSN: 0065-2598 [Print] United States
• PMID: 23224876 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• CREB1 protein, human
• Cyclic AMP Response Element-Binding Protein
• Hypoxia-Inducible Factor 1
• NF-kappa B
• Nerve Tissue Proteins
• Sodium-Calcium Exchanger
• sodium-calcium exchanger 1
• Sodium
• Calcium

Topics

• Animals
• Brain
• Brain Ischemia (metabolism, pathology)
• Calcium (metabolism)
• Cyclic AMP Response Element-Binding Protein (metabolism)
• Gene Expression Regulation
• Humans
• Hypoxia-Inducible Factor 1 (metabolism)
• NF-kappa B (metabolism)
• Nerve Tissue Proteins (metabolism)
• Neurons (metabolism, pathology)
• Sodium (metabolism)
• Sodium-Calcium Exchanger (biosynthesis)
• Stroke (metabolism, pathology)
• Transcription, Genetic