Abstract | BACKGROUND: METHODS: RESULTS: In naive mice, amitriptyline (20 mg/kg) increased withdrawal threshold to mechanical stimulation from 1.3 (0.6-1.9) (median [95% CI]) to 2.3 g (2.2-2.5) and latency of withdrawal to heat stimulation from 13.1 (10.4-15.5) to 30.0 s (21.8-31.9), whereas rufinamide had no effect. Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline). All drugs reduced peak current and stabilized the inactivated state of voltage-gated sodium channel Nav1.7, with similar effects in dorsal root ganglion neurons. CONCLUSIONS:
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Authors | Marc R Suter, Guylène Kirschmann, Cedric J Laedermann, Hugues Abriel, Isabelle Decosterd |
Journal | Anesthesiology
(Anesthesiology)
Vol. 118
Issue 1
Pg. 160-72
(Jan 2013)
ISSN: 1528-1175 [Electronic] United States |
PMID | 23221868
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Anticonvulsants
- Triazoles
- Voltage-Gated Sodium Channels
- Amitriptyline
- rufinamide
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Topics |
- Amitriptyline
(administration & dosage)
- Analgesics, Non-Narcotic
(administration & dosage)
- Animals
- Anticonvulsants
(pharmacology)
- Behavior, Animal
(drug effects)
- Disease Models, Animal
- Hyperalgesia
(complications, drug therapy)
- Mice
- Mice, Inbred C57BL
- Neuralgia
(complications, drug therapy)
- Physical Stimulation
- Triazoles
(pharmacology)
- Voltage-Gated Sodium Channels
(drug effects)
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