Abstract | BACKGROUND: METHODS: A retrospective study of 183 veterans with 25( OH)D level <30 ng/mL, who were treated with 50,000 IU per week of vitamin D2, was performed. Logistic regression models were developed to determine the factors predicting the response to treatment, defined as either the change in serum 25( OH)D level/1000 IU of vitamin D2 or the number of vitamin D2 doses (50,000 IU per dose) administered. RESULTS: The mean age of the patients was 63 ± 12 years. About 87% were men and 51% diabetic, and 29% had an estimated glomerular filtration rate of <60 mL/min/1.73 m. The average number of vitamin D2 doses was 10.91 ± 5.95; the average increase in 25( OH)D level was 18 ± 10.80 ng/mL. 25( OH)D levels remained <30 ng/mL in 61 patients after treatment. A low estimated glomerular filtration rate and the presence of diabetes mellitus were significant independent predictors for inadequate response to vitamin D2 treatment in logistic regression models. Patients with CKD required greater amounts of vitamin D2 to achieve similar increases in 25( OH)D levels, versus non-CKD patients. CONCLUSIONS: The presence of CKD and diabetes mellitus is associated with resistance to correction of 25( OH)D deficiency with vitamin D2 therapy. The underlying mechanism needs to be evaluated in prospective studies.
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Authors | Hala M Alshayeb, Barry M Wall, Arif Showkat, L Darryl Quarles, Therese Mangold |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 345
Issue 4
Pg. 314-320
(Apr 2013)
ISSN: 1538-2990 [Electronic] United States |
PMID | 23221508
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Diabetes Complications
(complications, drug therapy)
- Drug Resistance
- Ergocalciferols
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Renal Insufficiency, Chronic
(complications)
- Retrospective Studies
- Vitamin D Deficiency
(drug therapy)
- Vitamins
(therapeutic use)
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