[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].

Abstract

Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.

• Authors: B Le Luyer, J F Mougenot, L Mashako, P Chapoy, J P Olives, A Morali, B Chevallier, J L Ginies, C Dupont, M Dagorne
• Journal: Archives francaises de pediatrie (Arch Fr Pediatr) Vol. 47 Issue 1 Pg. 65-8 (Jan 1990) ISSN: 0003-9764 [Print] France
• Vernacular Title: Efficacité pharmacologique de l'alginate de sodium suspension sur le reflux gastro-oesophagien du nourrisson et de l'enfant.
• PMID: 2322080 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alginates
• Suspensions

Topics

• Alginates (administration & dosage, pharmacology, therapeutic use)
• Child, Preschool
• Female
• Gastroesophageal Reflux (drug therapy)
• Humans
• Hydrogen-Ion Concentration
• Infant
• Infant, Newborn
• Male
• Reference Values
• Suspensions