Abstract |
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
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Authors | B Le Luyer, J F Mougenot, L Mashako, P Chapoy, J P Olives, A Morali, B Chevallier, J L Ginies, C Dupont, M Dagorne |
Journal | Archives francaises de pediatrie
(Arch Fr Pediatr)
Vol. 47
Issue 1
Pg. 65-8
(Jan 1990)
ISSN: 0003-9764 [Print] France |
Vernacular Title | Efficacité pharmacologique de l'alginate de sodium suspension sur le reflux gastro-oesophagien du nourrisson et de l'enfant. |
PMID | 2322080
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Alginates
(administration & dosage, pharmacology, therapeutic use)
- Child, Preschool
- Female
- Gastroesophageal Reflux
(drug therapy)
- Humans
- Hydrogen-Ion Concentration
- Infant
- Infant, Newborn
- Male
- Reference Values
- Suspensions
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