[Epidural labor analgesia and parturient with type 2B von Willebrand disease].

Abstract

Type 2B von Willebrand disease (vWD) is an inherited bleeding syndrome resulting from a qualitative abnormality of von Willebrand Factor with an increased affinity for the glycoprotein Ib platelet receptor. Pregnancy increases the severity of this disease by decreasing the platelet count restricting epidural anaesthesia because of adverse risk of spinal bleeding. There is a phenotypic variability of Type 2B vWD depending of the von Willebrand Factor mutation. We report here the strategy we used to administer epidural anaesthesia for a patient with Type 2B vWD resulting from the P1337L mutation of von Willebrand Factor.

• Authors: J Lagarrigue, B Richez, B Julliac, L Saltel, P Nurden, F Sztark
• Journal: Annales francaises d'anesthesie et de reanimation (Ann Fr Anesth Reanim) Vol. 32 Issue 1 Pg. 56-9 (Jan 2013) ISSN: 1769-6623 [Electronic] France
• Vernacular Title: Analgésie péridurale obstétricale et maladie de Willebrand de type 2B.
• PMID: 23218955 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2012 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

Chemical References

• von Willebrand Factor

Topics

• Analgesia, Epidural (adverse effects)
• Analgesia, Obstetrical (adverse effects)
• Contraindications
• Female
• Hematoma, Epidural, Spinal (prevention & control)
• Humans
• Infant, Newborn
• Mutation
• Platelet Count
• Postoperative Hemorrhage (drug therapy)
• Pregnancy
• Young Adult
• von Willebrand Disease, Type 2 (complications, genetics)
• von Willebrand Factor (genetics)