HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of surgical wound classification on biologic graft performance in complex hernia repair: an experimental study.

AbstractBACKGROUND:
Despite relatively sparse data regarding their outcomes in the setting of infection, biologic grafts have gained rapid acceptance by the surgical community for complex hernia repair. These materials are heterogeneous in their procurement and processing techniques, which may ultimately have an impact in their ability to withstand infection. The objective of this study is to evaluate the impact of varying levels of contamination on biologic graft performance in a chronic ventral hernia animal model.
METHODS:
Four commonly applied biologic grafts were used in the repair of a chronic ventral hernia rat model (n = 218). Each material was repaired in the setting of 1 of 4 surgical wound classifications (clean, clean contaminated, contaminated, dirty infected) with Staphylococcus aureus as our inoculum agent. After a 30-day survival, repairs underwent quantitative cultures, histological, and biomechanical testing.
RESULTS:
Marked differences were observed in biologic graft bacterial burden, biomechanical and histological responses at 30 days. Persistent bacterial burden varied among the biologic grafts and increased with increasing wound contamination (P < .05). Delays in wound healing were observed in the contaminated and dirty infected setting (P < .05). Increasing infection weakened the biomechanical strength of repairs (P < .05).
CONCLUSION:
The degree of bacterial contamination at the time of repair affected the rates of bacterial clearance, wound-healing ability, and subsequent repair strength. Material source and processing techniques might alter graft durability, biocompatibility, and ability to clear bacteria in a contaminated field. Clinical trials are warranted in contaminated settings.
AuthorsKarem C Harth, Jeffrey A Blatnik, James M Anderson, Michael R Jacobs, Farhad Zeinali, Michael J Rosen
JournalSurgery (Surgery) Vol. 153 Issue 4 Pg. 481-92 (Apr 2013) ISSN: 1532-7361 [Electronic] United States
PMID23218885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Mosby, Inc. All rights reserved.
Chemical References
  • Biocompatible Materials
Topics
  • Animals
  • Biocompatible Materials
  • Female
  • Hernia, Ventral (surgery)
  • Herniorrhaphy
  • Rats
  • Rats, Sprague-Dawley
  • Staphylococcal Infections (etiology, pathology)
  • Staphylococcus aureus (growth & development)
  • Surgical Mesh
  • Surgical Wound Infection (microbiology, pathology)
  • Wound Healing

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: